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10
Feb
2019

Research Projects: Dec 2017-Dec 2018

 

Clinical Trials - $1,780,000
World-class clinical trials for Australians

BIOMEDE: New treatments for children with DIPG: $188,750 
Dr Geoffrey McCowage - Monash University 

  • An Australian first adaptive clinical trial to find new treatments for children with Diffuse Intrinsic Pontine Glioma (DIPG): 8 treatment centres across Australia and New Zealand.

 

Pilot study of Nivolumab in paediatric Patients: $86,796
Associate Professor David Ziegler - Australian and New Zealand Children's Haematology Oncology Group

  • A pilot study into the effects of nivolumab on hypermutant tumours in children.

 

Using immunotherapy to find new treatments for aggressive brain cancers: $500,000
Associate Professor Mustafa Khasraw - The University of Sydney

  • Sequential Immunoherapy in patients with underserved rare cancers (due to open 2020). 

 

 GBM AGILE: Test and develop brain cancer treatments quickly and cheaply: $1,000,000

  • A world-first international adaptive clinical trial to find new treatments for glioblastoma (pending).

 

Innovation Grants - $1,000,000
Do things differently: find a cure faster

Predicting a glioblastoma patient’s response to therapy and resistance to treatment: $200,000 
Prof Andrew Scott - La Trobe University

  • Imaging and molecular determinants of response to chemoradiation in glioblastoma.

 

 

Mixing traditional treatments with new drugs to improve outcomes: $200,000
Associate Professor Nick Gottardo - Telethon Kids Institute

  • Sensitising brain cancer to conventional treatment testing novel drugs for childhood and adult brain cancers. 

 

Understanding how epigenetic abnormalities lead to brain cancers: $200,000 
Associate Professor Lee Wong - Monash University

  • Investigation into epigenetic defects and new therapeutic strategy in ATRX mutated gliomas.

 

Drug targets for primary brain cancer in adults: $200,000 
Dr Leonie Quinn - The Australian National University

  • Determining how FUBP1 drives ligodendroglioma to develop more personalised treatments for primary brain cancer.

 

An Immunotherapy study to combat Glioblastoma: $200,000
Dr Roberta Mazzieri - The University of Queensland

  • Resetting the Tumour Microenvironment to Improve Glioblastoma Immunotherapy.

 

Early Career Fellowships - $690,000
Attracting the brightest young minds to solve the problem of brain cancer

T (CAR-T) cell therapies to recognise and kill tumour target cells: $345,000
Dr Ryan Cross - The Walter and Eliza Hall Institute of Medical Research

  • Designing Novel Chimeric Antigen Receptor T Cell Therapies for the Treatment of Paediatric and Adult Gliomas.

 

Identifying targeted therapies for a leading cause of cancer death in children: $345,000
Dr Laura Genovesi - The University of Queensland

  • Defining the anti-tumour efficacy of CDK4/6 inhibitors in combination with chemotherapy and possible mechanisms of resistance in murine and patient derived xenograft models of medulloblastoma, the most common melignant childhood brain cancer.
    Video courtesy of University of Queensland. 

 

Capacity Building Grants - $800,000
Boosting Australian research capacity  

Accelerating the pace3 of Australia-wide brain cancer research: $400,000
Dr Bryan Day - QIMR Berghofer Medical Research Institute

  • Evaluation of Novel Therapies for Brain Cancer and Generation and Characterisation of Recurrent Brain Cancer Models.

 

 

A platform resource for drug and genetic screening for brain cancer patients: $400,000
Dr Guillermo Gomez - University of South Australia

  • A national brain-organoid based high-throughput platform for personalised drug and genetic screening in glioblastoma.

 

Help fund vital brain cancer research