| Project title | Imaging and Molecular Determinants of Response to Chemoradiation in Glioblastoma |
|---|---|
Grant Amount | $200,000 |
Institution | La Trobe University |
Investigator Team | Principal investigators Prof. Andrew Scott, Prof. Anna Nowak, A/Prof. Roslyn Francis, A/Prof. Hui Gan and A/Prof. Mustafa Khasraw with associate investigators A/Prof. Brad Moffat, A/Prof. Kerrie McDonald, Prof. Roeland Verhaak, Prof. Robert Coffey and A/Prof. Dale Bailey |
Grant Type | 2018 Innovation Grant |
Years | 2018 – 2021 |
Professor Andrew Scott with a world-class team of clinicians and scientists from around Australia, will work on improving prognosis and better predicting a glioblastoma patient’s likely response to therapy, along with their likelihood of resistance to treatment.
They aim to achieve this by utilising an imaging technique for detecting amino acid metabolism in brain tumours using Positron Emission Tomography, in a clinical trial of over 200 patients. This information can be used to guide treatment regimens with glioblastoma and hopes to promote personalised therapies to improve survival for those with brain cancer.
“The Cure Brain Cancer Foundation grant is enabling sophisticated image analysis of PET and MRI scans in patients participating in a multi-centre Medical Research Future Fund (MRFF) funded trial, which we hope will allow more accurate treatment and improve glioblastoma patient outcomes”
Prof. Andrew Scott
Progress: First annual progress report (December 2019)
The infrastructure required to collect and analyse the large number of positron emission tomography (PET) images of 210 patients with brain cancer collected during the study has been developed. Efforts are underway to ensure the clinicians and 10 hospitals involved in the study are sufficiently experienced and assessed to ensure study procedures can be fully implemented. Methods to undertake computational analysis of the large quantities of imaging data are being developed.